New trends for metal complexes with anticancer activity

Anticancer Activity of Heterocyclic Ligand-platinum Metal Complexes

A wide range of research activities have been carried out so far on benzimidazole and pyridine derivatives to evaluate their Antiviral, Anticancer, Anticonvulsant, Anthelmintic Activity and many promising results are obtained with respect to the anticancer activity. Out of the various ligands used, the alkylating agents are found to be highly active with respect to cancer chemotherapy. Nitrogen...

Anticancer metal complexes and tumour targeting strategies

Unusual DNA binding modes for metal anticancer complexes.

DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis. New platinum drugs can be designed that have novel modes of interaction with DNA, such as the trinuclear platinum complex BBR3464. Also it is possible to design inert platinum(IV) pro-drugs which are non-toxic in the dark, but ...

Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide

Novel metal(II) complexes derived from 2-hydroxy-N'-((Z)-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide ligand (H2L) were synthesized and characterized by elemental and thermal analyses (DTA and TGA), IR, UV-VIS, (1)H-NMR, ESR and mass spectroscopy, magnetic susceptibilities, and conductivities measurements. The complexes adopt distorted octahedral geometry. The ESR spectra of the solid ...

Synthesis and Characterization of Metal Complexes with New Unsymmetrical Schiff Base Ligand Derived from 2-Aminoethanethiol

A new unsymmetric thioether diamine N - ( 2 - ( 2 - aminophenylthio) ethyl) benzene - 1 , 2 - diamine was prepared through the nucleophilic substitution of cysteaminium chloride with 1 - chloro - 2 - nitrobenzene and then the nitro groups of prepared compuond converted to the amine by zinc powder and ammonium chloride. Then, unsymmetric Schiff bass ligand 2 - ((( 2 - (( 2 - (( 2 - (( 2 - hydrox...